Preparation of manuscripts
Manuscripts should be prepared in accordance with the "Uniform Requirements for Manuscripts Submitted to Biomedical Journals: Writing and Editing for Biomedical Publication" as presented at http://www.ICMJE.org/.
The manuscript can be submitted in Chinese and English. If in English should bedouble-spaced throughout using 11pt Times New Roman/Arial, including for the title page, abstract, introduction, materials and methods, results, discussion, acknowledgements, references, umber pages consecutively, beginning with the title page. Gene symbols should be italicized; protein products are not italicized. Non-standard abbreviations should be defind when first used in the text.
Title Page The title page should carry 1) the title of the article, which should be concise but informative; 2) the name and the order of authors 3) the name of the department(s) and institution[s]/Hospital to which the work should be attributed; 4) disclaimers, if any; 5) contact information of the author responsible for correspondence about the manuscript; and 6) source[s] of support in the form of grants, equipment, drugs, or all of these; The of author
Abstract The abstract should briefly (no more than 150 words for unstructured abstracts or 250 words for structured abstracts) The abstract should state the purposes of the study or investigation, basic procedures (selection of study subjects or laboratory animals; observational and analytical methods), main findings (giving specific data and their statistical significance, if possible), and the principal conclusions. It should emphasize new and important aspects of the study or observations. 3-8 keywords or short phrases should be given. Terms from the Medical Subject Headings (MeSH) list of Index Medicus should be used; if suitable MeSH terms are not yet available for recently introduced terms,
Introduction The introduction should begin with a brief introduction of background related to the research and should be as concise as possible.
materials and methods Describe your selection of the observational or experimental subjects (patients or laboratory animals, including controls) clearly. Identify the age, sex, and other important characteristics of the subjects. The definition and relevance of race and ethnicity are ambiguous. Authors should be particularly careful about using these categories.
Identify the methods, apparatus (give the manufacturer's name and address in parentheses), and procedures in sufficient detail to allow other workers to reproduce the results. Give references to established methods, including statistical methods (see below); provide references and brief descriptions for methods that have been published but are not well known; describe new or substantially modified methods, give reasons for using them, and evaluate their limitations. Identify precisely all drugs and chemicals used, including generic name(s), dose(s), and route(s) of administration.
Reports of randomized clinical trials should present information on all major study elements, including the protocol (study population, interventions or exposures, outcomes, and the rationale for statistical analysis), assignment of interventions (methods of randomization, concealment of allocation to treatment groups), and the method of masking (blinding).
Authors submitting review manuscripts should include a section describing the methods used for locating, selecting, extracting, and synthesizing data. These methods should also be summarized in the abstract.
Ethics When reporting experiments on human subjects, indicate whether the procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional or regional) and with the Helsinki Declaration of 1975, as revised in 1983. Do not use patients' names, initials, or hospital numbers, especially in illustrative material. When reporting experiments on animals, indicate whether the institution's or a national research council's guide for, or any national law on, the care and use of laboratory animals was followed.
Statistics Describe statistical methods with enough detail to enable a knowledgeable reader with access to the original data to verify the reported results. When possible, quantify findings and present them with appropriate indicators of measurement error or uncertainty (such as confidence intervals). Avoid relying solely on statistical hypothesis testing, such as the use of P values, which fails to convey important quantitative information. Discuss the eligibility of experimental subjects. Give details about randomization. Describe the methods for and success of any blinding of observations. Report complications of treatment. Give numbers of observations. Report losses to observation (such as dropouts from a clinical trial). References for the design of the study and statistical methods should be to standard works when possible (with pages stated) rather than to papers in which the designs or methods were originally reported. Specify any general-use computer programs used.
Results The results should present the experimental data in tables and figures with suitable descriptions.
Tables These should be labeled sequentially as Table 1, Table 2, etc. Each table should be cited in the text. Reference to table footnotes should be made by means of Arabic numerals. Tables should not duplicate the content of the text. They should consist of at least two columns; columns should always have headings. Authors should ensure that the data in the tables are consistent with those cited in the relevant places in the text, totals add up correctly, and percentages have been calculated correctly. Supply tables as Word, Excel or HTML files (one table per file). Include the table title and legend in the table file.
Figures Figures and images should be labeled sequentially, numbered and cited in the text. Figure legends should be printed and double-spaced on a separate sheet titled ‘Titles and legends to figures’. Figures should be referred to specifically in the text of the paper but should not be embedded within the text. The use of three-dimensional histograms is strongly discouraged when the addition of the third dimension gives no extra information. If a table or figure has been published before, the authors must obtain written permission to reproduce the material in both print and electronic formats from the copyright owner and submit it with the manuscript. This follows for quotes, illustrations and other materials taken from previously published works not in the public domain.
For initial submission, figures could be embedded with the text as one Word file. For a revised manuscript, tiff , psd and jpeg are the only acceptable formats for the figures, which should be submitted separately. Use quality graphic programs such as Adobe PhotoShop, Adobe Illustrator, Corel Draw, or Freehand to create your figures. Figures should be approximately the same size as you would like them to appear in press.
Note: While an image may look perfect on the screen, it is often of insufficient resolution for publication. Try viewing your figure at 100% and 300 dpi in resolution on the screen; if it is not blurry, it is probably of high enough resolution for the printing process.
Figure legends Legends must be submitted for all figures. They should be brief and specific, and should appear on a separate manuscript page after the Reference section. Use scale markers in the image for electron micrographs, and indicate the type of stain used.
Discussion The discussion should focus on the interpretation and significance of the findings with concise objective comments.
Acknowledgments: The acknowledgements should be brief and include references to financial supports along with the numbers of grants.
References The references should include only articles that are published or in press. The references are each numbered, ordered sequentially as they appear in the text. List all authors unless there are more than 3, in which case only the first 3 should be given, followed by “et al”.
Please use the following style for references:
TESTA R, FRANCESCHINI R, GIANNINI E, et al. Serum leptin levels in patients with viral chronic hepatitis or liver cirrhosis[J]. J Hepatol,2000,33(1):33-37.
CLEARY MP, PHILLIPS FC, GETZIN SC, et al. Genetically obese MMTV TGFalpha/Lep(ob) Lep(ob) female mice do not develop mammary tumors[J].Breast Cancer Res Treat,2003,77(3):205-215.